How Treatment May Help


How Treatment May Help You

PROMACTA is the only platelet booster proven effective over a 7-year study in adults

Have other treatments such as steroids or IVIg not worked to keep your platelet levels stable or have they caused too many side effects?


PROMACTA® (eltrombopag) may be an option to treat your chronic ITP. It may boost your platelet counts and keep them safe and stable over time.


PROMACTA has been studied extensively for chronic ITP, including in 3 clinical trials for adults and 1 extension study that lasted 7 years. In all the studies combined, over 700 ITP cases were examined.


Did you know PROMACTA is FDA approved for children as young as 1 year old? Go here to learn about PROMACTA for chronic ITP in children.

PROMACTA raises platelets in a majority of patients

The first two 6-week studies (both looking at PROMACTA versus placebo) demonstrated that PROMACTA raises platelet counts to the target (50,000 per microliter of blood) for the majority of patients*:  59% in the first trial and 70% in the second trial.


Percent of patients who reached target platelet count levels in 2 trials of PROMACTA versus placebo. Trial 1: PROMACTA 58%, placebo 16%. Trial 2: PROMACTA 70%, placebo 11%.

PROMACTA may help keep platelet levels up

A third 6-month study looked at how PROMACTA can keep platelet levels up over time. In that study:

  • A sustained platelet response (platelet counts of 50,000 per microliter of blood or greater for at least 6 of 8 weeks) was achieved by 60% of patients taking PROMACTA (versus 10% with placebo)
  • 59% of the patients taking PROMACTA were able to stop their other chronic ITP medications (such as steroids or IVIg) 

Continued treatment with PROMACTA gave patients up to 7 years of lasting results

Finally, researchers took interested patients from the above trials and enrolled them in an extension study, which followed their progress on PROMACTA (with or without additional therapy) for 7 years. 

  • PROMACTA was effective in maintaining platelet counts in the desired range throughout the study
  • No new or increased side effects were identified

Eighteen patients continued the study all the way through its completion.


Curious how PROMACTA works? Find out here.

Who took part in PROMACTA trials for chronic ITP?

Expand all

The median age of PROMACTA patients in the trials was...

  • In trial 1: 47 years of age
  • In trial 2: 50 years of age*
  • In trial 3: 47 years of age
  • In the extension study: 50 years of age

*Total patient population.

  • In trials 1 and 2: 60% of patients were female
  • In trial 3: 69% of patients were female
  • In the extension study: 66% of patients were female

Did you know? Chronic ITP affects women at a rate of almost 2:1.

*Target levels defined as platelet counts greater than or equal to 50,000/mcL at the end of 6 weeks.

Target range defined as platelet counts between 50,000/mcL and 400,000/mcL during the 6-month period that patients received PROMACTA or placebo.

What to Expect When You’re Starting PROMACTA

Learning how to make a new medicine part of your routine can take time. Each of the patients below had a different concern about starting treatment with PROMACTA. Does anything sound familiar? While everyone is unique, you may find it helpful to learn about other people’s experiences.


Select each patient to learn more about his or her experience with taking PROMACTA.

When I first started taking PROMACTA, sometimes I took my medicine with food. But my doctor explained that PROMACTA only works if you take it exactly as prescribed. That means taking PROMACTA on an empty stomach, either 1 hour before eating or 2 hours after eating. It’s also important to take PROMACTA either 2 hours before or 4 hours after eating foods or taking medicines that keep my body from absorbing PROMACTA. These include dairy products, calcium-rich foods, antacids, multivitamins, and other supplements that contain iron, calcium, aluminum, magnesium, selenium, or zinc. Taking PROMACTA exactly as my doctor prescribed is how I do my part to help manage my condition.

I’ll be the first to admit that I’m not the most patient person in the world. So when I started on PROMACTA, I wanted to know immediately if it was working. But because you may not feel any difference, especially in the beginning, it’s hard to know. That’s why I liked having regular blood tests. You have to go every week for a platelet count and every 2 weeks to check your liver function, which was great because I could see the numbers for myself. Now that my PROMACTA dose is set, I only need to get blood tests every month.   

When my doctor first mentioned PROMACTA, I have to admit that I was uncertain about trying another medicine. But he explained that while my current medicine helped prevent existing platelets from being destroyed, PROMACTA actually increases the number of platelets being made. And the fact that PROMACTA is a once-a-day pill means that I can take it at the time that works best for me, wherever I am.

Being diagnosed with chronic ITP
Do you share any of the same thoughts or concerns as Anna, David, or Donna? Click here to read how other people have reacted to being diagnosed with chronic ITP.