Understanding Side Effects

PROMACTA for children

The most common side effects of PROMACTA® (eltrombopag) in children 1 year and older when used to treat second-line persistent or chronic immune thrombocytopenia (ITP) are:

  • Upper respiratory tract infection (symptoms may include runny nose, stuffy nose, and sneezing), 17%
  • Pain or swelling (inflammation) in their nose or throat (nasopharyngitis), 12%


No other side effects occurred in more than 9% of children in the 2 main pediatric studies of PROMACTA


Only 5% of children treated with PROMACTA in clinical trials (8 of 156) had to stop taking therapy due to side effects


Less common but more serious side effects that may occur with PROMACTA include:


  • Liver problems
  • Worsening of a precancerous blood condition to a blood cancer called acute myelogenous leukemia (AML)
  • High platelet counts and higher risk for blood clots
  • New or worsened cataracts (a clouding of the lens in the eye)

No matter what the treatment, always let your child’s doctor know about any side effects